Altos niveles de glucosa disminuyen la producción de testosterona

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Altos niveles de glucosa disminuyen la producción de testosterona

Notapor Fisio » Jue, 13 Mar 2014, 23:45

Int J Endocrinol. 2013;2013:684659. doi: 10.1155/2013/684659. Epub 2013 Dec 31.
Negative effects of high glucose exposure in human gonadotropin-releasing hormone neurons.
Morelli A1, Comeglio P2, Sarchielli E1, Cellai I2, Vignozzi L2, Vannelli GB1, Maggi M3.
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Abstract

Metabolic disorders are often associated with male hypogonadotropic hypogonadism, suggesting that hypothalamic defects involving GnRH neurons may impair the reproductive function. Among metabolic factors hyperglycemia has been implicated in the control of the reproductive axis at central level, both in humans and in animal models. To date, little is known about the direct effects of pathological high glucose concentrations on human GnRH neurons. In this study, we investigated the high glucose effects in the human GnRH-secreting FNC-B4 cells. Gene expression profiling by qRT-PCR, confirmed that FNC-B4 cells express GnRH and several genes relevant for GnRH neuron function (KISS1R, KISS1, sex steroid and leptin receptors, FGFR1, neuropilin 2, and semaphorins), along with glucose transporters (GLUT1, GLUT3, and GLUT4). High glucose exposure (22 mM; 40 mM) significantly reduced gene and protein expression of GnRH, KISS1R, KISS1, and leptin receptor, as compared to normal glucose (5 mM). Consistent with previous studies, leptin treatment significantly induced GnRH mRNA expression at 5 mM glucose, but not in the presence of high glucose concentrations. In conclusion, our findings demonstrate a deleterious direct contribution of high glucose on human GnRH neurons, thus providing new insights into pathogenic mechanisms linking metabolic disorders to reproductive dysfunctions.


http://www.ncbi.nlm.nih.gov/pubmed/24489542
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Fisio
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Re: Altos niveles de glucosa disminuyen la producción de testosterona

Notapor ZeRaTuL » Dom, 16 Mar 2014, 00:27

Fisio, encuentro poca cosa referente a la posible hipótesis de la reducción del sistema inmunitario referente a los altos niveles de glucosa ingeridos. Lo máximo es:
http://www.marksdailyapple.com/sugar-su ... ne-system/

¿Sabes de algo?
ZeRaTuL
 
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Re: Altos niveles de glucosa disminuyen la producción de testosterona

Notapor Fisio » Mar, 18 Mar 2014, 04:59

Evidencia anecdótica... lo cual no implica que no sea cierto, sino que no se ha investigado. O más habitual en estos casos, se ha investigado y no se ha publicado. Las tabacaleras tenían cientos de estudios sobre los riesgos del tabaco. Y los ocultaron. Y ahí siguen.

1. Cohn ZA, Morse SI. Functional and metabolic properties of polymorphonuclear leucocytes. 1. Observations on the requirements and consequences of particle ingestion. J Exptl Med 1960; 111: 667

2. Sanchez A, et al. Role of sugars in human neutrophilic phagocytosis. Am J Clin Nutr 1973; 26: 1180-84

3. Ringsdorf WM jr, Cheraskin E and Ramsey RR jr. Sucrose, Neutrophilic Phagocytosis, and Resistance to Disease. Dent Surv 1976; 52 (12): 46-48
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Re: Altos niveles de glucosa disminuyen la producción de testosterona

Notapor ZeRaTuL » Mié, 19 Mar 2014, 13:19

Gracias guapo. A leer.
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