El cannabis tan eficaz como los antipsicóticos y con menos efectos secundarios

La historia no contada de las drogas

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El cannabis tan eficaz como los antipsicóticos y con menos efectos secundarios

Notapor Fisio » Mié, 27 Ago 2014, 17:36

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia

F M Leweke1,2, D Piomelli3,4, F Pahlisch1,3, D Muhl2,3, C W Gerth2, C Hoyer1,2, J Klosterkötter2, M Hellmich5 and D Koethe1,2

1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
2Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
3Department of Pharmacology and Biological Chemistry, University of California, Irvine, CA, USA
4The Unit of Drug Discovery and Development, Italian Institute of Technology, Genova, Italy
5Institute for Medical Statistics, Informatics, and Epidemiology, University of Cologne, Cologne, Germany

Correspondence: Professor FM Leweke, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, J5, 68159 Mannheim, Germany. E-mail: leweke@cimh.de; D Piomelli, Department of Pharmacology and Biological Chemistry, University of California, Irvine, 3101 Gillespie Neuroscience Facility, Irvine, CA 91697-4625, USA. E-mail: piomelli@uci.edu

Cannabidiol is a component of marijuana that does not activate cannabinoid receptors, but moderately inhibits the degradation of the endocannabinoid anandamide. We previously reported that an elevation of anandamide levels in cerebrospinal fluid inversely correlated to psychotic symptoms. Furthermore, enhanced anandamide signaling let to a lower transition rate from initial prodromal states into frank psychosis as well as postponed transition. In our translational approach, we performed a double-blind, randomized clinical trial of cannabidiol vs amisulpride, a potent antipsychotic, in acute schizophrenia to evaluate the clinical relevance of our initial findings. Either treatment was safe and led to significant clinical improvement, but cannabidiol displayed a markedly superior side-effect profile. Moreover, cannabidiol treatment was accompanied by a significant increase in serum anandamide levels, which was significantly associated with clinical improvement. The results suggest that inhibition of anandamide deactivation may contribute to the antipsychotic effects of cannabidiol potentially representing a completely new mechanism in the treatment of schizophrenia.


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http://www.nature.com/tp/journal/v2/n3/ ... 1215a.html
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